Cluster of Differentiation 45 (CD45) polyHRP Anti-Human Staining Kit immunohistochemistry (IHC) reagent is for use on frozen and formalin-fixed-paraffin-embedded tissues. The CD45 antigen is a protein which was originally called Leukocyte Common Antigen and recognizes an antigen found on lymphoid cells. Anti-CD45 antibody is a useful tool for identifying tumor cells of lymphoid origin. It is routinely used to aid the differential diagnosis of undifferentiated neoplasms, whenever malignant lymphoma is suspected by morphologic clinical data. CD45 is a Type I trans-membrane protein which is in various forms present on all differentiated hematopoietic cells except erythrocytes and assists in the activation of those cells (a form of co-stimulation). It is expressed in Lymphomas, B-cell Chronic Lymphocytic Leukemia, Hairy Cell Leukemia, and Acute Non-lymphocytic Leukemia.
Both the 5ml and 10ml CD45 products are configured with the ready-to-use antibody only. Blocker, DAB, and wash buffer are not included in this product.
Instructions For Use: