Q-STAIN X (QSXTM)-Enh Anti-Human SOX10 antibody is intended for laboratory use to qualitatively identify by light microscopy the presence of SOX10 in sections of formalin-fixed, paraffin-embedded tissue sections or frozen tissues using immunohistochemistry (IHC) test methods. The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient’s clinical history and other diagnostic tests by a qualified pathologist/physician. This reagent has been formulated to ready-to-use
concentration and optimized for IHC use without further dilution.
Summary and Explanation:
QSX-Enh SOX10 is a ready-to-use rabbit monoclonal antibody reagent (Clone R1008). It is expressed in nuclei of melanocytes, peripheral nerve sheath cells, and breast myoepithelial cells. Positive nuclear staining for SOX10 is seen in breast basal-like, unclassified triple negative, and metaplastic carcinoma. SOX10 also shows an increased specificity for soft tissue tumors of neural crest origin compared with S100. SOX10 along with other markers like MITF1 may be useful in differentiating melanoma in situ from actinic keratosis with melanocytic hyperplasia. See Q-STAIN X. User’s Guide to learn more about test protocols.
