ihcDirect® TROP2 (calcium signal transducer 2) is a polyHRP conjugated rabbit monoclonal antibody (clone R1011). TROP2 is a 35 kDa transmembrane glycoprotein and functions as an intracellular calcium signal transducer. It promotes cell regeneration, proliferation, invasion and survival in normal tissues. TROP2 mutations may result in gelatinous drop-like corneal dystrophy and it can be overexpressed in carcinomas which may promote increased tumor aggressiveness and metastasis. TROP2 may be found in colorectal, gastric and pancreatic cancers, squamous cell cancers of the oral cavity, non–small cell cancers of the lung, as well as endometrial and ovarian malignancies.