Q-STAIN (QSXTM)-Enh Calponin antibody (Clone C126) is intended for laboratory use to qualitatively identify by light microscopy the presence of calponin in contractile smooth muscle and myoepithelial cells in sections of formalin-fixed, paraffin-embedded tissue sections or frozen tissues using immunohistochemistry (IHC) test methods. The clinical interpretation of any staining or its absence should be complemented by morphological studies using proper controls and should be evaluated within the context of the patient’s clinical history and other diagnostic tests by a qualified pathologist/physician. These reagents have been formulated to ready-to-use concentration and optimized for IHC on specific tissue application use without further dilution.
Summary and Explanation:
QSX-Enh Calponin is a ready-to-use mouse monoclonal antibody reagent (clone C126). The Calponin antibody reacts with calponin, which is a 34kD polypeptide that interacts with actin, tropomyosin, and calmodulin. Calponin is involved in smooth muscle contraction mechanisms and is expressed in smooth muscle tissue. It is also observed in myoepithelial cells.1,2 The Calponin antibody may be used as a marker of the differentiated contractile phenotype of developing smooth muscle and to help differentiate benign sclerosing lesions of the breast from carcinoma. See Q-STAIN X User’s Guide to learn more about test protocols.
